The A5 was closed between Gobowen Whittington following the crash which happened near the Five Crosses roundabout in Gobowen, near Oswestry, at around 2.45pm on Sunday.
The incident involved three cars of which two overturned and a third which came to rest down an embankment.
Paramedics and fire crews attended the scene following reports of a multiple-vehicle crash and that two people were trapped.
The road was reopened at around 4pm.
Oswestry Fire Station posted: "Three-car road traffic collision of which two had rolled after impact. One other vehicle came to rest down embankment of the A5.
"Reports of two casualties trapped, but upon arrival of the fire service they had self-extricated and where in the care of paramedics with head injuries."
The fire service added that all the vehicles were made electrically safe.
Motorists were advised to use alternative routes with traffic being diverted though Oswestry.
Oswestry Safer Neighbourhood Team tweeted: "@OsCops road traffic collision coming in on the A5 on the Five Ways roundabout. Several vehicles involved with two people trapped.
"Closures on the A5 between Gobowen and Whittington. Police, fire and ambulance on scene. Please avoid."