The biker died when his Ducati motorbike collided with a Honda Jazz car at around 1.40pm on the A49 by Prees Heath Common Nature Reserve,near Prees Heath Roundabout, where the road meets the A41.
West Mercia Police said the male motorcyclist was confirmed dead at the scene of the crash,while the two female occupants of the car were taken to Royal Stoke University Hospital.
The driver, who had to be cut out by firefighters, had serious injuries while the passenger had minor injuries.
The road was closed in the afternoon following the incident,with motorists told to find alternative routes.
North Shropshire Safer Neighbourhood Team (SNT) confirmed at 8.25pm that the road was now open again.
Shropshire Fire & Rescue Service said crews were called at 2.08pm. Three fire appliances, including the rescue tender, from Prees, Wellington and Whitchurch were sent after receiving a request from West Midlands Ambulance Service to assist at the scene. The Midlands Air Ambulance also attended.
Firefighters used cutters and spreaders once at the scene.