Two cars were involved in the crash which happened on Telford Way at Heathgates Roundabout, Ditherington, at around 2.30pm on Friday.
Two fire engines were sent from the nearby Shrewsbury station and cut free one casualty who was then treated by ambulance crews, Shropshire Fire and Rescue Service said.
The extent of their injuries has not yet been confirmed.
The closure led to major congestion in Shrewsbury, with the roundabout acting as a key link for drivers heading in and out of town and towards Sundorne and Battlefield.
Motorists were advised to avoid the area and seek seek alternative routes until the road was reopened.
West Mercia Police Operations & Communications Centre tweeted: "Road closure due to RTC, Heathgates roundabout, - very heavy traffic, please use an alternative route."