The loads will travel from 9.30am to 5pm on September 27 and 28, from Chester to Llandrindod Wells.
The route takes it close to Ruabon, Chirk, Gobowen, Oswestry, Four Crosses and Welshpool.
The Welsh Government's motorway and trunk road information service has warned drivers to "plan ahead and expect delays".
Approximate timings have been given for Wrexham at10:30am and Newtown at 2.05pm, Llangurig at 3:05pm and Crossgates at 4.30pm on both days.
Abnormal load movements are planned on these routes from 9:30-5pm on 27th-28th Sept⚠️— Traffic Wales North & Mid #KeepWalesSafe (@TrafficWalesN) September 24, 2021
Approx. timings are:#A483 Wrexham 10:30 Newtown 14.05#A470 Llangurig 15:05#A44 Crossgates 16:30
Plan ahead & expect delays⌚https://t.co/JO1MbrVWWB @CheshireRCU @PowysRPU