The collision happened at Kenstone, Hodnet, shortly before 7am on Tuesday.
A Shropshire Fire and Rescue spokesman said: "At 7.05am on Tuesday, January 31, SFRS Fire Control received a call reporting that a road traffic collision had taken place in Market Drayton involving two vehicles.
"One fire appliance was mobilised from Hodnet. Also at the scene of the incident were the land ambulance service and the police."
A West Midlands Ambulance Service spokeswoman said: "At 6.58am, we were called to reports of an RTC on the A53 near Hodnet in Shropshire.
"An ambulance and a paramedic officer were sent to the scene where, on arrival, they discovered one patient: a man. He was treated for possible serious injuries by ambulance crews before being taken to Royal Stoke Hospital for further treatment."