Three out of four lanes were closed on the M6 northbound in the Black Country due to the accident between Junctions Nine and 10, for Wednesbury and Walsall.
Motorists were urged to allow for extra travel time and consider other routes on Tuesday afternoon.
West Midlands Ambulance Service said the crash had involved a lorry and three cars.
Firefighters freed a man from one of the vehicles and he was taken to hospital.
A spokesman for West Midlands Ambulance Service said: "We were called by the fire service at 1pm to reports of a multi-vehicle collision on the M6 Northbound between junctions nine and 10.
"An ambulance, one paramedic officer and the West Midlands Care Team were sent to the scene where, on arrival, crews discovered a lorry and three cars had been involved in a collision.
"There was one patient, a man, who was removed from his car by fire colleagues and treated for potentially serious injuries before being taken to hospital for further treatment."
📍 #M6 between J9 (Wednesbury) and J10 (Walsall)— West Midlands Roads (@WMRoads) January 31, 2023
⚠️ Road traffic collision on this route
❌ 3 lanes closed (Traffic is passing the scene in lane 1)
⌛ 45 min delays impacting #M6 J7, #M5 J1 & routes around J9 & J7
⌚⤴️ Allow extra time & consider other routes@HighwaysWMIDS pic.twitter.com/JlyCrZhB9k
#M6 Northbound has 3 of 4 lanes CLOSED between J9 (Wednesbury) and J10 (Walsall / Wolverhampton) due to an accident - Road not expected to fully re-open before 15:00 - Latest @ https://t.co/HIDgkgnqLk pic.twitter.com/2BUnmjs45z— Motorway Cameras (@MotorwayCameras) January 31, 2023