West Midlands Ambulance Service was called to the incident on the B4379 near Sheriffhales by the fire service at 7.24am.
Two ambulances, a paramedic officer and the Midlands Air Ambulance critical care car from Cosford were sent to the scene.
A West Midlands Ambulance Service spokeswoman said: “When ambulance staff arrived, they found a car that had crashed into a tree and one patient, a man, who was the driver.
“He was found to be in a critical condition and was already receiving medical assistance from emergency service colleagues.
“Ambulance crews worked quickly to provide advanced life support but sadly, despite everyone’s best efforts, it became clear that nothing more could be done to save him and he was confirmed dead at the scene.”
West Mercia Police said: "The collision happened around 7am on the B4379 in Sheriffhales. For reasons yet to be established a vehicle collided with a tree.
"The driver, a 51-year-old man, was confirmed dead at the scene. His next of kin has been informed.
"Officers are carrying out enquiries and appealing for any witnesses."
Anyone who was on the road around the time of the incident and witnessed the collision, or has dash cam footage, is asked to email email@example.com.