West Midlands Ambulance Service (WMAS) was called to the crossing in Harlescott Lane at 12.15pm this afternoon.
Two ambulances and a paramedic officer, as well as officers from West Mercia Police, were sent to the scene.
WMAS spokesman Murray MacGregor said: "We were called to reports of a pedestrian in collision with a train.
"There was nothing that could be done to save the person.
"They were confirmed dead at the scene."
Drivers were urged to avoid the Harlescott area of Shrewsbury as emergency services dealt with an incident on the railway crossing.
British Transport Police said the incident is not being treated as suspicious.