The A49 through Dorrington, from the Stapleton junction to the railway bridge south of the village, will be worked on until May 15.
It will be closed between 8pm and 6am throughout the period, including until April 30 when it will be shut between Stapleton and Longnor.
During the closure, a 34.5-mile diversion will take motorists travelling north from Craven Arms to Aston Eyre via the B4368, and then to Bayston Hill via the A458 and the A5.
Access will be given to homeowners within the closure via a vehicle escort.
From May 3 to May 14, temporary traffic lights will be in place between Grange Lane junction and Stapleton junction.
Shropshire Council's highways contractors, Kier, will be undertaking the work to resurface the road and several areas of footpath, reset the kerbs, and renew the pedestrian crossing, technology and road markings.
Drain covers will also be replaced and reset between the Grange Lane junction and Stapleton Junction.