The A49in Shrewsbury was closed on Friday afternoon after two cars crashed at the Battlefield Island, with motorists warned to avoid the area.
One woman has been rushed to hospital in a serious condition, while a second has been treated for injuries not believed to be serious and taken to hospital for further treatment.
A spokesperson from West Midlands Ambulance Service said: "We were called at 3:06pm to reports of a two car RTC on the A49 in Upper Battlefield.
"We sent two ambulances, a paramedic officer and the Midlands Air Ambulance Critical Care Car with a trauma doctor and critical care paramedic onboard.
"We have treated a woman in a serious condition, she’s been conveyed to Royal Stoke University Hospital on blue lights and sirens for further treatment.
"A second woman has been treated for injuries not believed to be serious and has also been conveyed to hospital for further treatment.”
Police said delays were expected due to the crash, which saw one car 100 per cent involved in fire.
Fire crews from Shrewsbury attended the scene and an operations officer was also in attendance.
West Mercia Police Operations & Communications Centre tweeted: "A49 Shrewsbury closed at Battlefield Island due to a road traffic collision.
"Delays are expected, please find alternative routes."
The incident involved two cars and fire crews used breathing apparatus and a hosereel jet to deal with the fire.