Emergency services were on the scene of the serious collision on the A442 at Quatt.
It happened just before 11.30am.
Police say the road was closed after the crash with a large build-up of traffic in both directions.
"Please avoid the area if you can," a police spokesperson said.
The AA's roadwatch page said the road was closed both ways between Chapel Lane and the Claverley turn-off, affecting traffic between Bridgnorth and Alveley.
The air ambulance is believed to have been scrambled to the scene.