National Highways bosses said Walsall's Junction 10 southbound exit slip road would close from 9pm on Saturday.
It forms part of a major £78 million project at the junction designed to cut congestion, with the scheme expected to be completed this year.
This slip road closure will be in place from 9pm on March 11 until 5am on March 13.
A spokesman said: "We’re sorry for the disruption these closures may cause to your journey and encourage drivers to plan ahead and allow extra time when travelling. Please note that these closures are subject to change at short notice due to unforeseen circumstances or poor weather conditions."