Lawley Primary School messaged parents last night let them know that it had been advised to close from today for a deep clean.
The school has been open to children whose parents are key workers.
In the letter the school said that it hopes to reopen as soon a possible, but is unable to set a date.
It has also given an update on groups who attend some of the schools clubs who must self isolate as a result of the situation.
The letter said: "Unfortunately, due to a high number of Covid-19 cases within the school we have been advised by Telford and Wrekin Health Hub that the school should temporarily close to enable us to undertake a deep clean.
"The school site will therefore be closed to all children tomorrow. The school will be able to reopen as soon as a deep clean has been undertaken but unfortunately we are unable to give a date for this.
"We appreciate the frustration this may cause and can assure all parents that such a step follows the guidance provided by the Health Hub and is undertaken in the best interests of the children, staff, and parents at Lawley Primary School."
It added: "Any children that were at Breakfast Club or Afterschool Club on Thursday, January 7, Friday, January 8, or Monday, January 11, must isolate for 10 days from the last date that they attended – counting the date of attendance as day 0. If you are unsure about this information please email the school for further guidance."