The two-car smash happened near All Stretton at around 7.25pm on Saturday.
The main road was closed in both directions between Church Stretton and All Stretton as a result did not reopen until about 1.25am the following morning.
The fire service reported there were "several casualties", including at least on person who was trapped. The extent of any injuries is not yet known.
West Midlands Ambulance Service and West Mercia Police were also at the scene.
Shropshire Fire & Rescue Service sent two appliances from Church Stretton and Craven Arms.
An operations officer was also sent and crews used small gear, working with other emergency services, to make the area safe.
West Mercia Police confirmed an investigation into the crash had been launched.
The fire service reported: "Road traffic collision involving two vehicles, vehicles made safe by fire service personnel, several casualties in care of ambulance service."
The ambulance service has been contacted for more information.
The incident came hours after another road in Shropshire was closed due to a crash.
Police shut the B4398 in both directions between Knockin and Llynclys at about 10.30am.
Motorists were advised to avoid the area.