The man was driving a Vauxhall Astra which was in collision with a stationary lorry at Stafford Park 4 at about 7.45pm last night.
Three fire crews from Telford and Wellington stations were called to the incident to cut the man free from the car.
A West Midlands Ambulance Service spokesman said: "Crews arrived to find a car that had been in collision with a lorry.
"The driver of the car, a man in his 40s, had suffered a significant head injury in the collision and was quickly treated by medics.
"He was immobilised with the use of a neck collar and spinal board before being anaesthetised due to the serious nature of his condition. He was then transported to Royal Stoke University Hospital.
"Unfortunately the man's injuries are thought to be extremely serious. The lorry driver was uninjured in the incident."
Police are appealing for witnesses to the crash.
A spokesman said: "A green Vauxhall Astra was travelling along Stafford Park 4 and approaching the nearside junction for Stafford Park 10, when it was in collision with a heavy goods vehicle which was stationary at the junction.
"The driver of the Vauxhall Astra, a man in his late 30s, sustained a serious head injury and was taken to North Staffordshire Hospital where he remains in a critical but stable condition.
"The driver of the heavy good vehicle, a 49-year-old man, was uninjured. The road was closed after the collision and reopened at around 11pm."
"Police are eager to hear from anyone who witnessed the collision or the circumstances leading up to it. Information can be given to police by calling 101 quoting incident 564S of Tuesday February 24."