Work taking place until about June 14 will include pothole, footpath and drainage work near Shrewsbury and the replacement of street lighting near Nesscliffe.
It is due to begin on May 3 at Emstrey Roundabout and along the A5064 when contractors will conduct footway and drainage maintenance.
Shropshire Council said the area will see various closures as a result.
This includes lanes four and five of the A5 westbound leading to Emstrey Roundabout; the dedicated lane leading from the southbound carriageway of the A5064 to the eastbound carriageway of the A5 and all footpaths near to the roundabout.
The work is set to be carried out overnight between 8pm and 6am and continue until May 15.
A diversion route will be signed from April 26 and will go via the A5, A49 and A5112 junction.
From May 17, a four-week closure is set to come into force along the A5 near Nesscliffe from Felton Butler Roundabout to Wolfshead Roundabout.
Vehicles approaching Felton Butler Roundabout from the westbound A5 and Holyhead Road will be controlled by traffic lights while the work to replace street lights is undertaken.
It will see the eastbound and westbound carriageways of the A5 between the roundabout junction with Holyhead Road and the unnamed road leading to Felton Butler closed, as well as the roundabout junction with the B4396 and Holyhead Road, northwest of Nesscliffe.
The slip road leading from the southbound carriageway of the A5 to Nesscliffe Service Station will also be shut along with adjacent laybys.
Traffic will not be able to join Felton Butler Roundabout from the hamlet itself and nearby footpaths and cycleways will also be closed.
Lastly, a further closure seeks to fix a number of potholes along the A5 between Emstrey Roundabout and Preston Island near Shrewsbury.
The work will take place overnight from 9pm on May 18 until 6am the following morning.