The collision occurred near The Swan at Forton on the A519 Eccleshall Road in Forton, near Newport, shortly after 3pm on Saturday.
Officers from both Staffordshire and West Mercia Police have been called to the scene, along with a crew from Shropshire Fire and Rescue Service and air ambulance.
A spokesman for the fire service said a crew from Newport were called about a collision between a car and a motorcycle at 3.17pm.
On Sunday, Staffordshire Police confirmed that the 72-year-old motorcyclist died at the scene.
Telford Cops have also tweeted describing the crash as 'serious', and warning motorists to avoid the area if possible, as have Newport Cops.