The two vehicles collided on the A528, which links Shrewsbury and Ellesmere at Preston Gubbals by the junction for Bomere Heat and Merrington near St Martin's Church, about five miles north of the county town.
The road has been closed for most of the afternoon since the collision shortly after midday.
West Midlands Ambulance Service was called at 12.22pm, and sent two ambulances, a paramedic officer and the Midlands Air Ambulance from Staffordshire to the scene.
A spokesman said: “On arrival crews discovered a male motorcyclist in a critical condition.
“Ambulance staff immediately began administering advanced life support but sadly, despite their best efforts, it became apparent nothing could be done to save the man and he was confirmed dead at the scene.”