Goldsmiths of Shrewsbury in the Square was vandalised over the weekend.
It appears that a watch display in the window was the target.
Higher end watches and jewellery at the store retail for upwards of £5,000.
Police taped off a large area outside the shop to try and preserve the crime scene and gather evidence.
It is not known what was taken.
This is just the latest incident in a spate of anti-social behaviour in Shrewsbury.
Over the Easter Bank Holiday weekend, Strands hairdressers in Grope Lane had a window smashed, with expensive hair straighteners and hair dryers stolen.
There were also a number of violent incidents in Shoplatch, illegal gatherings in the Quarry and a case of staff being abused by youths at a convenience store in Sundorne.
Police have said there will be a strong presence in the town this week.