North Wales Police said the A5 was completely closed south of the Halton Roundabout to the Gledrid Roundabout at about 4.16pm on Saturday.
Traffic Wales North & Mid also warned of reports of a collision and that emergency services were at the scene.
The road was re-opened at 5.53pm and motorists were thanked for their patience.
The Wales Ambulance Service and North Wales Police have been asked for more information.
