The A41 Crickmerry was closed following the fatal crash at around 11am on Sunday.
Emergency services were called but the man and woman were confirmed dead at the scene.
The road was shut for at least seven hours while an investigation got under way.
Police say the crash involved two vehicles. Officers appealed for witnesses to come forward with any information.
Anyone who witnessed the collision is urged to get in contact with West Mercia Police on 101 quoting reference 251s 240319.
Morning from Team A. Emergency services are dealing with a serious RTC at Crickmerry, Market Drayton which is off the A41. Road closures are in place please find a different route.— West Mercia OCC (@WestMerciaOCC) March 24, 2019