CUPS Coffee & Creators is moving into the old Country Linens and Interiors building opposite Dough and Oil on Castle Street.
James and Nicole Bradbury, the owners of CUPS, already run a coffee shop in Chester which will now be joined by their new venture in Shrewsbury.
CUPS in Chester offers people the chance to play board games while eating and drinking.
The Shrewsbury branch - in the ground floor of a Grade II listed building - will include retail space for independent creators.
Nicole explained: “Our brand, CUPS, is keen to work with the local communities and to develop areas that will benefit Shrewsbury. For this reason our Shrewsbury store will be a little different from our Chester store. Enter CUPS Coffee & Creators.
“We are creating a quirky retail space for small, independent makers – giving our creators a space on the high street to sell their unique products.
“Although we love board games we have an opportunity to challenge ourselves and create something new and fresh – and we can't wait.”
Toby Shaw, who handled the letting for Towler Shaw Roberts, said: “CUPS Coffee & Creators will be another excellent addition to the town centre and it’s always nice to attract new businesses to Shrewsbury.
"The property is located prominently within the ‘Castle Quarter’ area, which has been earmarked by Shropshire Council for an exciting regeneration scheme, with a range of initiatives planned.
"The property also has the benefit of a canopy, which offers the potential for an outside seating area.”