The 35-year-old featured for 65 minutes on Tuesday night, while Molineux team-mate Ruben Neves came off the bench.
Neves got an assist as well, setting up Cristiano Ronaldo as the Manchester United man completed a hat-trick.
Nelson Semedo was an unused sub for Portugal, who sit second in Group A.
Conor Coady also stayed on the bench as England drew 1-1 with Hungary at Wembley.
Elsewhere, Romain Saiss played the full 90 minutes as Morocco enjoyed a 4-1 World Cup qualifying win in Guinea.
Hwang Hee-chan was not taken off either as South Korea drew 1-1 in Iran.
At under-21s level, Fabio Silva got an hour under his belt as Portugal won 1-0 against Iceland. Netherlands U21s enjoyed an impressive 5-0 triumph over Wales, with Ki-Jana Hoever coming on in the 74th minute.
Raul Jimenez’s Mexico, meanwhile, were facing El Salvador in the early hours of this morning.