The defender recently missed two months with a calf injury but returned for last week's Good Friday defeat at Northampton.
He was due to make a second start in four days on Easter Monday at home to Plymouth but pulled out of the side as a precaution 10 minutes before kick-off, with Ro-Shaun Williams stepping in.
Assistant boss Aaron Wilbraham said the calf concern this time around is separate to the considerable muscle problem that kept Pierre sidelined for 12 games.
Shrewsbury visit Gillingham on Saturday with a decision still to be made on Pierre's availability as the muscle continues to settle down.
"He's settled down a little bit since Monday," Wilbraham said. "We're just seeing how it is at the moment.
"Hopefully if it keeps settling down he won't be too bad.
"Sometimes you have to wait and let the injury settle down before you have to scan it, I think that's what the physios are in the process of doing.
"They are deciding whether it needs scanning or whether it is reacting properly.
"We're letting them make the decision and giving us the information once they've been through the process."
Town are boosted, however, by the news that versatile midfielder Brad Walker is nearing a return from a groin problem.
Walker had only recently returned from three months out with an ankle injury before pulling up with the muscle issue.
He is set to travel with the squad to Kent tomorrow, as 17th-placed Town prepare for an overnight stay to help break up the lengthy journey south east.
Right wing-back Josh Daniels has also stepped up his rehabilitation from a calf injury.
The converted winger has not featured since coming off in the win at Burton a couple of weeks ago, but has began running outside at the club's Sundorne Castle training base.