Police are urging anyone who witnessed the crash last night to come forward.
Ambulance crews arrived to find an off-duty police officer and two off-duty nurses performing CPR and using a defibrillator on the motorcyclist who had come off his bike.
Despite the best efforts of crews and others involved, the man died at the scene, officers said.
It happened at around 11.45pm and the road was closed for several hours.
Police said a red Suzuki motorcycle travelling southbound collided with a signpost near the roundabout with Whitemeadow Close.
Anyone who saw the incident or captured it on dash cam is asked to get in touch.
National Highways bosses confirmed the road is now open, saying: "This incident is now clear, and the A49 in Shropshire is now OPEN in both directions at Craven Arms.
"Thanks for your patience if this closure affected your journey this morning."
West Midlands Ambulance Service received several 999 calls reporting the collision.
A spokeswoman said: "We received several 999 calls reporting a collision involving a motorcyclist and a lamppost on the A49 Shrewsbury Road in Craven Arms at 11.34pm on Wednesday. Two ambulances and a paramedic officer were sent to the scene.
"When ambulance staff arrived on scene, they found an off-duty police officer and two off-duty nurses performing CPR and using a defibrillator on a man who had come off his motorcycle.
“Crews quickly took over treatment but sadly, despite the best efforts of everyone at the scene, nothing could be done to save the man and he was confirmed dead a short time later.”