The man, aged in his 50s, was critically injured when he was hit by a lorry at the junction of Carver's Close and Holyhead Road in Wellington at 8.35am.
He was taken by air ambulance to the major trauma centre at Royal Stoke University Hospital.
Jamie Arrowsmith for the West Midlands Ambulance Service said: "Two ambulances, a paramedic officer and the Welsh Air Ambulance attended the scene. On arrival we discovered one patient, a man, who was the pedestrian.
"He was found in a serious condition and received specialist trauma care at the scene before being airlifted to Royal Stoke University Hospital for further treatment."
West Mercia Police are appealing for witnesses and dashcam footage.
A spokeswoman said: "At around 8.45am a man in his 50s was involved in a collision with a lorry on Holyhead Road, Wellington.
"The man was taken to Royal Stoke Hospital by air ambulance with potentially life threatening injuries and he remains in a critical condition.
"Anyone with information or dashcam foortage is urged to contact 101 quoting reference 00121i of 2 June."