The A5 between the B5069 and the B5009 near Gobowen has flooded resulting in the road being closed in both directions.
Earlier today, five people were trapped in two vehicles on the A5 in the Gobowen area by shallow flood water.
Firefighters and ambulance staff worked together to rescue and assess all five.
Storm Cristoph's impact is still being felt across Shropshire and the wider region.
A statement from Highways England said: "Highways England contractors are working to resolve the issue but the road remains closed for public safety.
"Road users are advised to expect delays and allow extra time for their journeys.
"Road users are being diverted via local roads."
Police are on the scene trying to help.
The A41 at Bletchley, near Market Drayton, is also shut due to flooding.
The #A5 in BOTH directions #FiveCrossesIsland (#B5069 #Oswestry #Gobowen) to #Gobowen (#B5009 #Gobowen) is currently CLOSED due to flooding in the carriageway. @WMPolice are currently at scene, Maintenance Crews are on their way to the area to assist.— Highways England (@HighwaysWMIDS) January 20, 2021