The A518 from Telford's clocktower roundabout to Kynnersley Drive, Lilleshall, will be closed to all traffic between 9.30am and 6.00pm for resurfacing works.
Diversion routes are set to be put in place but heavy good traffic faces a longer way around because of weight restrictions in the area.
Newport Cops tweeted: "Please note A518 from Telford (Clocktower r/bout) to Lilleshall (Kynnersley Dr) will be CLOSED TO ALL TRAFFIC from Monday 22nd Nov for 14 days between 9.30am & 6.00pm for resurfacing works.
"Newport bound traffic via The Humbers
"Telford bound traffic via Wellington Rd, Muxton."
Lorry drivers face a longer diversion. Newport Cops explained on Twitter: "Due to weight restrictions on the diversion routes, Newport bound HGV traffic will need to divert via A4640 Donnington Wood Way / Redhill Way, A5 to Pickmere Island and A41 north to Newport.
"Telford bound HGV traffic needs to divert the reverse of above."