The demolition, at the former Ironbridge Power Station, will be the fourth major piece to have taken place at the site since it was decommissioned.
Harworth Group, which owns the site and is clearing it ahead of proposals to redevelop it with around 1,000 homes, said the next demolition is scheduled for 10am to 2pm, Saturday, February 27.
The firm said the work would see it demolish the former power station's 'Boiler Bay' building.
The group said an exclusion zone would be in place and asked people with respiratory conditions to stay indoors, during and immediately after the demolition takes place.
A spokesman added that the date is provisional, and could change depending on the weather.
He said: "It is important to note that while the demolition is planned for this date and time, there may be adverse weather conditions or other circumstances that could cause a delay or possible postponement of the demolition.
"Should this be the case, Harworth will issue further statements to advise on its timetable.
"Harworth’s principal concern is to bring the Boiler Bay down safely, in full compliance with Covid-19 restrictions and the Section 81 notice issued by Shropshire Council for this purpose.
"To protect everyone on site and in the local area a 250m safety exclusion zone will be in place shortly before, during and for a period after the explosion to which there will be no public access.
"The blowdown will not need any major road closures.
"In addition, the blowdown of the Boiler Bay will generate dust. The vast majority of dust generated by the blowdown will fall within the Boiler Bay’s immediate vicinity. There remains the possibility however that some dust will be carried beyond the 250m exclusion zone. Therefore, any local residents with respiratory conditions are advised to stay indoors during and immediately after the demolition takes place."
Details of the exclusion zone are available at ironbridgeregeneration.co.uk