The crash happened in Overton Road shortly before 5pm. Three fire engines were sent as well as paramedics and the police.
A spokesman for West Midlands Ambulance Service said: "We were called to reports of a four-vehicle collision on Overton Road, Ludlow, at 4.38pm.
"Two ambulances and a paramedic officer attended the scene.
"On arrival we discovered two women, one of whom was driving one of the cars and one who was a passenger in a separate vehicle.
"They were both treated for injuries not believed to be serious before being taken to Royal Shrewsbury Hospital.
"A man was assessed and discharged at the scene whilst two further men did not wish to be assessed."
A Shropshire Fire and Rescue spokesman said: "At 4.48pm on Tuesday, October 4, SFRS Fire Control received a call reporting that a road traffic collision had taken place in Ludlow.
"Three fire appliances including the rescue tender were mobilised from Craven Arms, Ludlow and Wellington. An operations officer was in attendance."
Crews used cutters and spreaders and small gear, and also gave oxygen and first aid before paramedics arrived. The casualties were initially reported as trapped, but had been helped from the vehicles by the time emergency crews arrived.
Those who were hurt were left in the care of medics. The road was closed while emergency crews worked at the scene.