West Mercia Police's Operations and Communications Unit said that the crash had taken place on the B4380, Oteley Road.
The crash is said to have involved "three saloon vehicles". Although nobody was trapped, West Midlands Ambulance Service was called with paramedics treating casualties at the scene.
Posting on Twitter at around 4.40pm the force urged people to avoid the area.
Officers said the crash had taken place at the junction with Sutton Road.
Shropshire Fire and Rescue Service have also attended the scene,.
They said they had been called to the incident at around 3pm and had sent two crews to the scene where they made the vehicles safe.
Posting on Twitter the fire service said the crash had involved multiple vehicles.
They said: "Crews are currently dealing with a three vehicle RTC on Oteley road, Shrewsbury. The road will be closed for some time, please find alternative routes."