Emergency services received a 999 call at 1.23pm on Sunday afternoon to reports of a two-vehicle collision on the B4386 between Shrewsbury and Cruckton.
Both of the drivers, a man and a woman, had sustained serious injuries and were treated at the scene by ambulance crew before being taken to Royal Stoke University Hospital.
The 51-year-old man died despite the best efforts of paramedics, and the woman is being treated for life-changing injuries.
Police have said that one of the vehicles, a blue Ford Focus, had been seen driving erratically in Shrewsbury town centre.
It was driven from The Gap car park at Raven Meadows at around 12.45pm and travelled along Roman Road and Mytton Oak Road before joining the B4386.
Officers would like to hear from anyone who saw this car being driven or captured it on dashcam.
Anyone with any information is asked to visit westmercia.police.uk/tua/tell-us-about/ quoting ref 297 of November 14.
Two ambulances, a paramedic officer and the Midlands Air Ambulance from Cosford with a MERIT trauma doctor and critical care paramedic on board were sent to the scene and treated both patients.