Shropshire Council's north planning committee will be asked to make a decision on a request to demolish the former Riverside Medical Practice in Shrewsbury.
The demolition would be the first stage in wider plans that could see a complete redesign of the Riverside and Smithfield Road areas of the town.
The council has plans to demolish most of the existing buildings in the area – including the Riverside Shopping Centre – to create a new waterfront destination.
The committee will be asked to approve the demolition of the former medical practice, which has now moved to the former Tannery in the town.
Officers recommend going ahead with the plan.