The two-car collision happened on the A53 between Battlefield and Astley shortly before 9am.
The driver of one of the vehicles, a woman, was trapped following the crash, and was taken to hospital with potentially serious injuries.
A man, the other driver, did not suffer substantial injuries and was discharged by paramedics at the scene.
All three emergency services attended the incident, as well as the Midlands Air Ambulance (MAA) from Cosford.
West Mercia Police closed the road for a short time while the area was made safe.
Shropshire Fire & Rescue Service (SFRS) sent two appliances and an operations officer from Shrewsbury.
Crews used cutting and spreading equipment to free the woman who had become trapped, before leaving her in the care of the ambulance service.
West Midlands Ambulance Service (WMAS) sent one vehicle and a paramedic officer.
An ambulance spokesman said: "We were called to reports of a two-car collision on the A53 in Astley at 8.54am.
"One ambulance, a paramedic officer and the MAA from Cosford attended the scene. On arrival we discovered two patients.
"The driver of one of the cars, a woman, had to be cut out of her vehicle by the fire service. She was treated for potentially serious injuries by ambulance staff before being taken to Royal Shrewsbury Hospital.
"The second patient, a man, who was the driver of the second car, was discharged at the scene."