Last year the organisers had to cancel the mass event and instead put on a virtual race with athletes running the 26.2 miles from their homes.
So successful was it that another virtual event will be held this year at the same time as the race - which is music to the ears of Shropshire runner, Bryony Webster.
Bryony, 25, who lives near Ellesmere, has autism and knows she would not be able to line up with thousands of others at the face-to-face event.
But she says the virtual marathon allows her to test herself over the distance, gain her medal and raise money for charity.
She only took up running two years ago and is pleased with her achievement so far.
"I started running for my mental health as I was not in a good place. I find that it is good for me to have something positive to focus on."
She will be raising money for the Motor Neurone Disease Association.
"I was made aware of how many people really are suffering from the disease. I hadn't realised how many had to deal with it but it doesn't get the awareness that cancer does."
"I am doing this with the hope that they find a cure to this awful disease that changes so many lives for the worse."
Anyone who wants to help Bryony raise money can do so via justgiving.com/fundraising/Bryony-Webster2.