Highways England says it is embarking on a scheme of resurfacing, sign replacement and general maintenance along the trunk road.
Laybys between the end of the M54 at Junction 7 in Telford and Gobowen, near Oswestry, will also be affected.
Work will start on September 18 and will last for eight weeks.
The overnight road closures between 8pm and 6am will be restricted to the Oswestry bypass, between the Mile End Roundabout and the Gobowen roundabout.
Between September 30 and October 12 there will be a 40mph speed restriction along the Oswestry bypass.
A spokesman for the Highways Agency, Richard Gulliver, said that the work will extend south but it will only be laybys that will periodically be closed along the route between Mile End and the start of the M54 at Wellington.
“In the Oswestry area diversion routes will be via the A458 and the A483 and along the B5009 and the A495,” Mr Gulliver said.
He said that vehicles being used by the emergency services and also by the special forces will be exempt from the speed limit.