Emergency services were called to Manor Farm in Spoonley, near Market Drayton at around 11.10am on Friday.
Police, land ambulance and the air ambulance were sent to the scene where a man had suffered serious injuries.
Four fire appliances, including the rescue tender, wer also mobilised from Hodnet, Market Drayton and Wellington.
A spokesman from West Midlands Ambulance Service said: "We were called at 11.10am to reports of a collision involving a tractor and a van on Manor Farm in Spoonley, Shropshire.
"We sent one ambulance, a paramedic officer and the Midlands Air Ambulance from Tatenhill to the scene.
"On arrival, we found one patient, a man, who had sustained serious injuries, he was given treatment on scene and conveyed to Royal Stoke University Hospital by air ambulance for further assessment."