Paramedics were called to Steel Road in Tilstock near Whitchurch shortly after 6.40pm on Thursday.
The injured man, who has not been named, was flown to a major trauma centre.
The county's fire and rescue service said the incident involved a car and a motorbike.
A West Midlands Ambulance Service spokeswoman said: “On arrival, crews found the motorcyclist, a man, who’d been involved in a collision.
“He was treated for serious injuries at the scene before being conveyed via air ambulance to Royal Stoke University Hospital for further treatment.”
A crew based at Prees Fire Station and an operations officer were among the first to arrive at the scene and administered first aid to the motorcyclist.
West Mercia Police, an ambulance, a paramedic officer and the Midlands Air Ambulance based at Tatenhill, Staffordshire, with two critical care paramedics aboard attended the incident.