The smash happened on the A458 Bridgnorth to Stourbridge road at Six Ashes at 1.55pm.
Firefighters and ambulance crews were called to the scene where the car had caught fire. Earlier reports had suggested both vehicles were no fire.
Inspector Emma Wright of West Mercia Police said: "I can confirm there has been a serious collision involving a car and a motorcycle.
"Police sealed off the road, and fire and ambulance crews are also in attendance."
The Midlands Air Ambulance was also scrambled to the scene from RAF Cosford along with an ambulance and a rapid resonse vehicle.
The car's driver was taken to hospital in Dudley.