The incident happened at about 11pm on Wednesday at Newport Fire Station on Salters Lane.
Panels at the entrance to the fire station were smashed and the door was damaged.
It is believed the offenders were driving a Volkswagen estate.
A spokesperson from the fire station said: At 11pm we were yet again broken into by youths in a VW estate, possibly silver in colour.
"If anyone has any information that could lead to the apprehension of them, can they call 101 or our fire control."
Anyone with information should call West Mercia Police on 101 or Shropshire Fire & Rescue Service fire control on 01743260290.
Alternatively, contact Crimestoppers anonymously on 0800555111 or crimestoppers-uk.org