An unknown objector has sprayed messages in the centre of Madeley and on hoardings enclosing the closed Beacon pub at Hill Top.
The advent of the vaccine has been accompanied by a wave of conspiracy theories and anti-vaccination messages being spread online.
A banner reading "Fraud Pandemic" has been hung on the old pub and nearby graffiti carries slogans such as "Vaccination = Sterilisation = Depopulation" and "Love Them, Protect Them, Never Inject Them."
Similarly themed messages in the town's shopping centre comparing the current situation to a police state and George Orwell's "1984" have already been removed.
Telford & Wrekin Council has said in a statement that it is working with local police to try to find who is responsible for the spate of graffiti.