Work to pull down buildings in and around the Flax Mill site in Castlefields is well under way with contractors completing the demolition of the 24m high North Silo last week as part of multi-million pound plans to redevelop the site.
The historic Flax Mill has stood derelict for 30 years.
Campaigners hope to see businesses, arts groups, bars, restaurants and eventually homes created at the site if funding can be secured.
Now, the Friends of the Flax Mill Community Arts Group has launched a project to brighten up the hoardings.
They are calling on schools, youth groups, families and individuals to create artwork which celebrates the past, present and future of the area.
Richard Benjamin, community arts co-ordinator said: "We are really excited about this project and the interest that has already been shown.
"We will supply boards for people to work on and then treat and mount them on the hoardings."
David Purslow, the headteacher of the nearby Martin Wilson School, is leading the project.
He said: "I am delighted to be involved in this project which is open to all. Any group or person can use photographs, paint or other media to decorate the boards."
By Catherine Ferris